Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.
The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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Target Protein Ligand-Linker Conjugates Related Products (138)
Related Products (138)
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BMS-1166-N-piperidine-CO-N-piperazine
0 ImagesCat. No.: HY-131386CAS No.: 2447066-14-8BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM.
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K-Ras ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-129775CAS No.: 2749492-84-8K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
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K-Ras ligand-Linker Conjugate 4
0 ImagesK-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
![SMARCA2 ligand-13 PYR-Pip-spiro[3.3]heptane-acid](https://file.medchemexpress.com/product_pic/hy-169490.gif "Click to View SMARCA2 ligand-13 PYR-Pip-spiro[3.3]heptane-acid Product Detail")
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DDR1 ligand 1-piperidine
0 ImagesCat. No.: HY-176187CAS No.: 3081612-71-4DDR1 ligand 1-piperidine is a target protein ligand and linker conjugate, which can be used for the synthesis of PROTAC DDR1 degrader-1 (HY-176184).
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EGFR Ligand-Linker Conjugates 1
0 ImagesCat. No.: HY-176788CAS No.: 2768472-86-0
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Crizotinib-amide-PEG2-NH2
0 ImagesCat. No.: HY-176950CAS No.: 3048497-52-2Crizotinib-amide-PEG2-NH2 is a MET ligand (HY-50878) linker conjugate. Crizotinib-amide-PEG2-NH2 can be used for synthesis of MET degrader OZD-MET 01 (HY-177893).
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FAK ligand-2-C6-amine
0 ImagesCat. No.: HY-179515CAS No.: 2414478-60-5FAK ligand-2-C6-amine is a target protein ligand linker conjugate that contains a FAK ligand (HY-151010) and a PROTAC linker (HY-W011561), which can recruit E3 ligases. FAK ligand-2-C6-amine can be used for synthesis of BSJ-04-146 (HY-179512).
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Ahx-DM1
0 ImagesCat. No.: HY-147050CAS No.: 1702356-21-5Ahx-DM1 (compound 2A) is a conjugate of protein/peptide which can be combined with a therapeutic, diagnostic or labelling agent.
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K-Ras ligand-Linker Conjugate 6 formate
0 ImagesCat. No.: HY-130991APurity: 98.93%K-Ras ligand-Linker Conjugate 6 formate incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 formate can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
